植物表观遗传学研究组

植物组蛋白去乙酰化酶作用模式研究取得重要进展

组蛋白的乙酰化与去乙酰化修饰在真核生物的基因转录调控中起到重要的作用。核心组蛋白的乙酰化通常引起染色质呈现“开放”的结构,从而促进基因的转录;而去乙酰化则导致染色质“关闭”进而抑制基因的转录。组蛋白的去乙酰化修饰由和组蛋白去乙酰化酶(histone deacetylase,HDAC)所催化。组蛋白的去乙酰化修饰在植物基因组的稳定性、转录调控和发育等过程中起到重要的作用。同时,研究表明组蛋白去乙酰化酶通常与各种染色质重塑蛋白和转录因子等相互作用,从而参与植物发育相关的转录抑制过程。本研究组刘勋成和杨松光博士等综述了植物组蛋白去乙酰化酶在基因转录抑制中的作用模式。相关的研究成果发表在Molecular Plant (2014, 7:764-772)。

Working Model of Plant Histone Deacetylases

Reversible histone acetylation and deacetylation at the N-terminus of histone tails play crucial roles in regulation of eukaryotic gene activity. Acetylation of core histones usually induces an “open” chromatin structure and is associated with gene activation, whereas deacetylation of histone is often correlated with “closed” chromatin and gene repression. Histone deacetylation is catalyzed by histone deacetylases (HDACs). A growing number of studies have demonstrated the importance of histone deacetylation on genome stability, transcriptional regulation, and development in plants. Furthermore, HDACs were shown to interact with various chromatin remolding factors and transcription factors involved in transcriptional repression in multiple developmental processes. Dr. Xuncheng Liu and Songguang Yang et al. summarized recent findings on the transcriptional repression mediated by HDACs in plants. The findings were published in Molecular Plant (2014, 7:764-772).

附图.植物组蛋白去乙酰化酶的作用模式
Figure. Working Model of Plant Histone Deacetylases

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